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• Advanced in toto immunohistochemistry to decipher the host response during Trypanosoma carassii infection*.

Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections.

Jacobs SH, Dóró E, Hammond FR, Nguyen-Chi ME, Lutfalla G, Wiegertjes GF, Forlenza M. Elife. 2021 Jun 11;10:e64520. doi: 10.7554/eLife.64520. PMID: 34114560

• 3D imaging of trout fry for comparative anatomical analysis of conventional and axenic animals*.

Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect against Flavobacterium columnare infection.

Pérez-Pascual D, Vendrell-Fernández S, Audrain B, Bernal-Bayard J, Patiño-Navarrete R, Petit V, Rigaudeau D, Ghigo JM. PLoS Pathog. 2021 Jan 29;17(1):e1009302. doi: 10.1371/journal.ppat.1009302. eCollection 2021 Jan. PMID: 33513205

• A review on the current knowledge about cGAS: structure, function and evolution from bacteria to metazoa

Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing.

Verrier ER, Langevin C. Front Immunol. 2021 Feb 23;12:637399. doi: 10.3389/fimmu.2021.637399. eCollection 2021. PMID: 33708225 Free PMC article. Review.

• Tissue clearing and 3D imaging to unravel host-pathogen interactions.

New Look at RSV Infection: Tissue Clearing and 3D Imaging of the Entire Mouse Lung at Cellular Resolution.

Frétaud M, Descamps D, Laubreton D, Rameix-Welti MA, Eléouët JF, Larcher T, Galloux M, Langevin C. Viruses. 2021 Jan 28;13(2):201. doi: 10.3390/v13020201. PMID: 33525646 Free PMC article.

• BATF3:eGFP: a new tg line to investigate development of vascular and lymphatic networks

 New reporter zebrafish line unveils heterogeneity among lymphatic endothelial cells during development.

Frétaud M, Do Khoa N, Houel A, Lunazzi A, Boudinot P, Langevin C. Dev Dyn. 2020 Dec 28. doi: 10.1002/dvdy.286. Online ahead of print. PMID: 33369805

• Animal Models for the Study of Nucleic Acid Immunity: from basic research to drug screening strategies.

Animal Models for the Study of Nucleic Acid Immunity: Novel Tools and New Perspectives.

Vila IK, Fretaud M, Vlachakis D, Laguette N, Langevin C. J Mol Biol. 2020 doi: 10.1016/j.jmb.2020.08.016.

• Comparative study of STING-dependent inflammation in vitro and in zebrafish larvae.

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.

Guerra J, Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N.

Sci Adv. 2020 May 22;6(21):eaax3333. doi: 10.1126/sciadv.aax3333. eCollection 2020 May. PMID: 32494729

• Novel tissue clearing method adpated to mouse hemi-head for global description of RSV cellular tropism in the nasal cavity.

Respiratory syncytial virus tropism for olfactory sensory neurons in mice.

Bryche B, Frétaud M, Saint-Albin Deliot A, Galloux M, Sedano L, Langevin C, Descamps D, Rameix-Welti MA, Eléouët JF, Le Goffic R, Meunier N.

J Neurochem. 2019 Dec 7:e14936. doi: 10.1111/jnc.14936. PMID:31811775

• Tissue clearing and deep imaging of porc skin biopsy to identify Ag expressing cells upon DNA vaccine administrations.  

A DNA Prime Immuno-Potentiates a Modified Live Vaccine against the Porcine Reproductive and Respiratory Syndrome Virus but Does Not Improve Heterologous Protection.

Bernelin-Cottet C, Urien C, Fretaud M, Langevin C, Trus I, Jouneau L, Blanc F, Leplat JJ, Barc C, Boulesteix O, Riou M, Dysart M, Mahé S, Studsrub E, Nauwynck H, Bertho N, Bourry O, Schwartz-Cornil I.

Viruses. 2019 Jun 25;11(6). pii: E576. doi: 10.3390/v11060576. PMID:31242645

• 3D analysis of whole porcine lumph node combining advanced IHC, tissue clearing and light sheet imaging. 

Macrophage-B Cell Interactions in the Inverted Porcine Lymph Node and Their Response to Porcine Reproductive and Respiratory Syndrome Virus.

Bordet E, Frétaud M, Crisci E, Bouguyon E, Rault S, Pezant J, Pleau A, Renson P, Giuffra E, Larcher T, Bourge M, Bourry O, Boulesteix O, Langevin C, Schwartz-Cornil I, Bertho N.

Front Immunol. 2019 May 3;10:953. doi: 10.3389/fimmu.2019.00953. eCollection 2019. PMID:31130951

* IERP unit is acknowledged for its assistance with 3D phenotyping.