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PREDICT - a strategic research initiative : Predictive Biology for Health

Research Strategy Initiative
PREDICT is a research initiative coordinated by SAPS units (Sciences Animales Paris-Saclay), supported by the Life Sciences Department of the University Paris-Saclay. This initiative which is both multidisciplinary and multi-community includes research teams working in the animal sciences, plant sciences, medical research, fundamental biology and infectiology, biostatistics and modeling, ethics and law. PREDICT provides an environment for research and discussion to promote actions in the field of predication for health. It is part of a societal approach with support from the House of Human and Social Sciences of the Paris-Saclay University.

These approaches for health are also at the heart of research currently being led in animals and plants, with the shared objective of favoring resistance to pathogens and environmental stress factors while reducing the use of antibiotics and phytosanitary products in order to promote the ecological transition in agriculture.

Within a scientific and socio-econmic context where health research is still largely being performed in silos, decompartmentalization wishes have emerged. The One Health initiative (One World, One Health), which is aimed at associating research in human and animal health in relation with the environment, is emblematic of this approach. The anchoring of INRA research teams in the University Paris-Saclay has created original opportunities on the theme of predictive biology for health, with the possibility of comparing medicine and precision farming. PREDICT is an offshoot.

Three complementary actions have been proposed:
  1. create scientific animation at the interface of the life, human and social sciences; 
  2. develop a methodological network for the analysis of heterogenous and complex data for predictive modeling;
  3. develop robust and sensitive methods for the large-scale detection of circulating miRNA in biological fluids for their use as biomarkers in man, animals and plants.
Amongst the results:
  • publication of the proceedings of a conference prepared in relation with the House of Human and Social Sciences of Paris-Saclay on the theme, "Predictive approaches for health: cross-referencing the socio-economic and scientific issues in humans, animals and plants".
  • two workshops for data analysis whose programs and presentations are available on-line. Over one-hundred scientists participated in the workshop held at Jouy-en-Josas on "Heterogenous and high-throughput data integration for the discovery of predictive markers". A second workshop "Deep learning and genomics" held at INRA Versailles gathered approximately 200 participants, reflecting the interest for methods associated with neuron networks, which today are experiencing an upsurge of interest with "Deep Learning" applied to massive amounts of data. 
  • comparison of different methodological approaches for the detection of circulating miRNA located in human, animal and plant biological fluids and the identification of the most sensitive and reliable method (nine teams contributing from the University Paris-Saclay).

The ineractions with the SHS Paris-Saclay communities reinforce the opportunites for interdisciplinary projects. The challenge of associating teams that study animals, plants and man has given us the chance to decompartmentalize the thematic silos, in particular on the shared questions of global health (one's health depends on the health of others).
The methodological network on multispecies detection of biomarkers in biological fluids organized a restitution seminar in February, 2019.

See also

Main Contact :

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Bibliography