Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay UVSQ ANSES CNRS ENVA

Home page

A condensate-hardening drug blocks RSV replication in vivo in Nature on 07 July 2021

@INRAE-Nicolas Bertrand (Coloration de lame avant l'observation au microscope dans l'UMR (ANSES-INRA-ENVA) de biologie moléculaire et immunologie parasitaire à l'ENVA de Maisons-Alfort.)
In this article we show the action of an antiviral compound targetting the respiratory syncytial virus, a pneumovirus responsible for brochiolitis and pneumonia in young children and calves. This studied involved a three-team partnership: the teams directed by Ralf Altmeyer (Shandong University, China), Marie-Anne Raleix-Welti (UVSQ- U. Paris-Saclay) and J.-F. Eléouët (VIM, INRAE, U. Paris-Saclay).

Pneumoviruses are responsible for respiratory diseases that can be severe (bronchiolitis, pneumonia) in man and animals; they infect the epithelial cells of the host and induce the formation of inclusion bodies (IB) in cells. These IB are viral factories where RNA is synthesized. They form by the exclusion of the liquid phase a little like droplets of oil in water but are organized by protein-protein or protein-RNA interactions with generally the implification of proteins with disordered domains. These organelles have no membrane and are located in the cells and their nucleus: nucleoli, stress granules etc. We identified a molecule, cyclopamine (CPM), that disturbs these viral structures. We show that CPM disorganizes the IB by changing their physical-chemical properties and notably by hardening these liquid droplets. In addition, we have separated the toxic action of CPM (activation of the Hedgehog pathway) on the cell from that tareting the virus.

DOI : 10.1038/s41586-021-03703-z.

Contact : Jean-François Eléouët

See also

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions. Choi JM, et al. Annu Rev Biophys. 2020. PMID: 32004090 Review.

New Perspectives on the Biogenesis of Viral Inclusion Bodies in Negative-Sense RNA Virus Infections. Dolnik O, Gerresheim GK, Biedenkopf N.Cells. 2021 Jun 10;10(6):1460. doi: 10.3390/cells10061460.