Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal AgroParisTech Université Paris-Saclay UVSQ ANSES CNRS ENVA

Home page

Relation between intestinal microbiota composition and influenza A virus vaccination response in pigs

INRAE
A study led by the Genetics, Microbiota, Health team of GABI shows that in pigs, a relation exists between the intestinal microbiota composition and the immune response to a vaccine against the influenza A virus (IAV) in pigs. The intestinal microbiota before vaccination has both high and low responders to vaccination and contains predictive information about these levels of response. A higher level of some bacteria genera was found to be associated with a better immune response to the vaccine.

Individual variability of vaccine response can weaken the level of protection of a herd. Identifying and predicting the causes are ways research can improve health and welfare on farms.

The intestinal microbiota interacts with the immune system via its host. Our study was aimed at analyzing the relation with the intensity of vaccine response in pigs vaccinated against IAV. The animals were vaccinated upon weaning at 28 days of age (J28), with a challenge three weeks later. Their immune responses to vaccination were followed by specific antibody assays and hemaglutination tests at different times:  early (on the day of challenge), at the peak of response (1 to 2 weeks after the challenge) and before slaughter between 140 and 150 days of age (long-term persistance of antibodies). The microbiota was characterized by sequencing of the RNAr 16S gene from fecal DNA and analysis of operational taxonomics units (OTU).

We observed a higher pre-vaccination microbial richness of the fecal microbiota in high responders to the vaccine compared to low responders with an overabundance of Prevotella and Muribaculaceae genera OTU. On the contrary, lower responders presented a higher abundancy of  Helicobacter Bacteroides, Christensenellaceae R7-group, Succinivibrio and Escherichia-Shigella genera OTU. These bacterial genera suggest that the associations identified implicate mechanisms associated with free fatty acid synthesis favoring the stimulation of the immune system or LPS with variable immunomodulating properties. At day 28, we also identified a group of 81 OTU predictors of response peak intensity.

These promising results must undergo additional studies before they can be used in vaccination protocols.

Reference:
Borey M, Blanc F, Lemonnier G, Leplat J-J, Jardet D, Rossignol M-N, Ravon L, Billon Y, Bernard M, Estellé J, Rogel-Gaillard C. Links between fecal microbiota and the response to vaccination against influenza A virus in pigs. npj Vaccines 6, 92 (2021). https://doi.org/10.1038/s41541-021-00351-2

Contact :

  • Marion Borey (marion.borey(at)inrae.fr)
  • Claire Rogel-Gaillard (claire.rogel-gaillard(at)inrae.fr)

See also

Financing :

European H2020 SAPHIR Project "Strengthening Animal Production and Health through the Immune Response" (http://www.h2020-saphir.eu/) ; Crédit Agricole Ile de France Sponsoring (young talent programme

Core and Experimental Facilities: