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Last update: May 2021

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A few examples of our scientific results

@INRAE Hervé Acloque

Scientific seminar on "Genome editing for research in the Animal Sciences"

22 November, 2022 FIAP Jean Monet, Paris 14th district

The working group on genome editing invites you to a scientific seminar on "Genome edition for research in the Animal Sciences" on November 22, 2022...

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Publication Clin Epigenet, Costes & al.

Predicting male fertility from sperm methylomes: application to 120 bulls with hundreds of artificial insemination records

Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental...
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Heatmap d'expression des clonotypes les plus partagés chez les poissons immunisés

Comparison of clonotypic IgH repertoires in the pronephros and spleen of a Teleost fish upon sytemic viral infection

In fish that are deprived of lymph nodes, the kinetics and location of B responses are poorly characterized. The pronephros is the site of...
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Publication Front Immunol, Thorel M. & Al. (BIPAR)

Assessment of the Safety and Efficacy of an Oral Probiotic-Based Vaccine Against Aspergillus Infection in Captive-Bred Humboldt Penguins (Spheniscus humboldti)

Aspergillosis is a major cause of morbidity and mortality in captive-bred penguin species. Currently, there is no registered vaccine to prevent...
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@BREED (Results of the immunohistochemical analysis of the MEI1 protein in the seminiferous tubules from a control (A) and a carrier patient (A’) in the homozygous state of a pathogenic variant  of the gene C11ORF80)

How can the analysis of the genome change how patients with azoospermia are managed?

This study which was published in Human Reproduction evaluated the relevancy of Whole Exome Sequencing (WES) in patients for which a first testicuar...
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@INRAE Delphine Rousseau-Ralliard Légende : A summary of the feto-placental effects of maternal exposition to a high-gat diet  either during preconceptional or gestational periods

High-fat maternal diet affects offspring phenotype: importance of windows of exposure

Being overweight or obese, in association with a high-fat diet is a major problem for public health, especially in women of childbearing age. We...
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@INRAE Amelie Bonnet-Garnier Legend:  3D Organization of rRNA genes at the 4-cell and 8-cell stages detected by 3D-DNA-FISH. (Top) z-section of a nucleus from an early embryo (E) or late (L). (Bas) Amira 3D Representation of each nucleus.

Chromatin transcription and reorganisation go hand in hand

We showed that ribosomal genes (rDNA) are organized in a unique manner in the embryo (very differently than somatic cells) between the 4-cell and...
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@INRAE Emilie Derisoud

Estimation of milk production in lactating mares and factors influencing milk yield

Research on mare milk is mainly concentrated on quality and information on quantity is incomplete, mainly since there has been no consensus on a...
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@ Alejandro_Cabezas-Cruz. Légende : Inducing infection-refractory states in vector microbiome. (a) Chains of infection of vector-borne diseases such as those transmitted by ticks involve matching (black lines) among competent vectors (red circle), infectious pathogens (blue circle) and an infection-compatible microbiome (yellow circle). (b) Mismatches between at least two of the components can result in an impaired ability of the vector to transmit pathogens. (c) Microbiome manipulation using anti-microbiota vaccines that elicit microbiota specific antibodies can be used to induce infection-refractory states (gray lines) in vector microbiome in which microbiome manipulation results in transmission blocking despite matching between pathogen and vector genetics (black line). Created with and taken from (Parasit Vectors. 2022;15(1):4. doi: 10.1186/s13071-021-05122-5)

Anti-microbiota vaccine reduces avian malaria infection within mosquito vectors

In this study, we showed that anti-microbiota vaccination in birds targeting Enterobacteriaceae bacteria within mosquito midguts modulates the...
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@INRAE D. Boichard

Publication of dairy catlle indexes estimated with the "Single Step" method

Single Step is a genomic evaluation method that simultaneously uses all animals, whether genotyped or not, in only one step. It is a major evolution...
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