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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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The H2020 RUMIGEN project - an 18-partner European consortium

European commission
The idea behind the RUMIGEN project is the adaptation of ruminants to climate change, which is becoming more and more prevalent, with the development of new breeding strategies likely to "buffer" its effects. Three SAPS units are implicated in this project: UMR BREED, GABI and VIM.

The RUMIGEN project is aimed at improving genomics selection in cattle (Holstein and other breeds), using three scientific levers of animal biology:

  • (i) quantitative genetics (WP3 & 4),
  • (ii) new technologies for targeted gene modifications (GE : Genome Editing, WP5), and epigenetics (WP6 & 7).

In addition to these biological levers, the RUMIGEN project involves human and social sciences levers (WP2) in order to propose new selection methods validated by European citizens (WP8 & 9) susceptible to being accepted more favorably by society than certain current practices including some which also be the object of an evaluation (Insemination Artificial, Embryo transfer, for example).

The WP3 & 4 are aimed at amongst others, taking into account the behavior of animals during periods of high temperature (heat waves) in selection schemes and widening the selection criteria to increase animal resilience (take into consideration genotype/environment interactions).

The WP5 will make an assessment of different examples where the GE could be useful in ruminants, will test the putative impact of GE on de novo mutation rates and finally will propose two practical examples of GE in goats and sheep.

The WP6 & 7 are aimed at developing a high throughput epigenotyping tool (chip), to test this tool to determine DNA methylation profiles in different tissues and different breeding conditions, and in the end, to integrate these epigenotyping data in genomic selection equations if the epigenetic determination decreases the variable part (unknown) of the present equations.

Towards improvement of ruminant breeding through genomic and epigenomic approaches
EU H2020 Project with 18 partners across EU with a total grant of ca. 7 Million € for all partners for 4 years.
Short title : Genomics and Epigenomic approaches in Cattle Breeding
Acronym : RumiGEN
Effective start/end date 01/03/2021 → 01/03/2025
Keywords : Genomics, Epigenetics, Bioinformatics, Cattle,  Breeding, Sustainability, Quantitative, Genetics, Greenhouse, gas emissions
Coordination: E. Pailhoux / INRAE-Tranfert (WP1)
Budget global 7 M€
Consortium RUMIGEN : 18 partners including 5 French (INRAE, INRAE-Transfert, ALLICE, IDELE et VALOGENE), 3 Danish (DBT : Danish Board of Technology, Aarhus University, Technological University of Danemark) 1 Italian (EAAP), 3 Dutch (EFFAB and Wageningen Research & Univ.), 1 Belgian (GIGA-Liège), 2 Spanish (INIA and IRIAF), 1 Norwegian (NMBU : Norwegian University for the Life Sciences), 1 Swedish (SLU : Swedish University for the Agricoltural Sciences) and1 Scottish (Univ. Edimbourg – ROSLIN Inst.).