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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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The BREED unit has a PhD position available (with financing, beginning in Octobre, 2022)

INRAE
The subject is: "Induction of dormancy in pluripotent cells and mammal embryos."

Abstract

Embryos of some mammals are capable of slowing down or even stopping their development when the environmental conditions are unfavorable (diapause, Fenelon et al, 2014). The mechanisms implicated to maintain the developmental potential (which are still poorly understood) seem to favor and even reinforce this potential. Several experimental methods allowing to obtain a cell state in vitro that is close to develomental diapause exist; they can be applied to pluripotent stem cells and explanted in vitro embryos  (Van der Weijden et al, 2021). These methods use metabolic pathways such as the mTOR pathway. We developed a new method for experimental in vitro dormancy induced by low-temperature anoxia. In these conditions, the embryonic stem cells cease to prolifer but maintain their cell identity for several days. Interestingly, the embryos from mice undergoing this dormancy react differently according to their developmental stage. This contrasted situation, in addition to the cell model, questions what physiological status allows cells to become receptive to dormancy induction. In the first part of this paper, we identify the functional pathways mobilized for entrance into experimental dormancy in order to understand how they contribute to maintaining cell potentiality. We treat the question about the conservation of these functional pathways between  species, using embryonic cells and bovine embryos, a species that naturally does not undergo diapause.

See also

Local contact Doctoral school
Dr Alice JOUNEAU ABIES (ED581),
alice.jouneau@inrae.fr Université Paris-Saclay
UMR BREED, bat 230, INRAE 78350 Jouy-en-Josas http://www2.agroparistech.fr/abies/
+33 1 34 65 25 68

Correspondent : Pierre Larraufie
site internet pierre.larraufie@agroparistech.fr
+33 (0) 1 45 49 88 51

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