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Dernière mise à jour : Mai 2018

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SPS - Saclay Plant Sciences

MERCI

Reaping the benefits of improved meiotic recombination for crop improvement

Partners

- Institut Jean-Pierre Bourgin (IJPB)
Team: Meiosis & Recombination
- UMR Quantitative Genetics and Evolution - Le Moulon (GQE-Le Moulon)
Team: Recombination of Alleles in Meiosis: Determinism, Applications and Modelling 
- Consortium of seed companies : KWS, SECOBRA and MARS

Abstract of the project

Unleashing the power of meiotic recombination through crossovers (COs) is a major challenge in plant breeding but the associated benefits are expected to be huge. With the advent of modern breeding, the low overall amount of COs and the existence of large genomic regions almost completely devoid of any COs have become limiting factors for crop improvement. To overcome these constraints, we will (i) show that CO rate can be increased in crops (using Oilseed Rape as a model) by knocking-down genes that were shown to encode negative regulators of CO in Arabidopsis thaliana, (ii) identify and characterize genes encoding proteins that affect CO distribution (a key point for breeders) and (iii) analyse the impact of increased CO number and/or reshaped CO distribution on selection response in breeding programs through both computer modeling and proof of concept selection cycles.
This project harnesses the complementary and internationally recognized expertise of the partners to translate cutting-edge meiotic research into plant breeding innovations. It is designed to empower plant breeders by manipulating the frequency and distribution of COs, enabling them to drastically accelerate their programs to develop new crop varieties.

Publications (as of September, 2019)

Blary, A., Jenczewski, E. (2018). Manipulation of crossover frequency and distribution for plant breeding. Theoretical and Applied Genetics, 1-18. , DOI : 10.1007/s00122-018-3240-1

Capilla-Perez L, Solier V, Portemer V, Chambon A, Hurel A, Guillebaux A, Vezon D, Cromer L, Grelon M, Mercier R. (2018) The HEM Lines: A New Library of Homozygous Arabidopsis thaliana EMS Mutants and its Potential to Detect Meiotic Phenotypes. Front Plant Sci, 9:1339.

Pfalz M., Gonzalo A., Christophorou N., Blary A., Berard A., Bessoltane N., Montes E., Jaffrelo L., Poncet C., Le Paslier M.C., Nesi N., Charif D. and Jenczewski E. (2020) Identifying and Isolating Meiotic Mutants in a Polyploid Brassica Crop. In: Pradillo M., Heckmann S. (eds) Plant Meiosis. Methods in Molecular Biology, vol 2061. Humana, New York, NY

Tourette E., Bernardo R., Falque M. and Martin O. (2019) Assessing by Modeling the Consequences of Increased Recombination in Recurrent Selection of Oryza sativa and Brassica rapa. G3 (Bethesda). 2019;9(12):4169–4181.

Communications in conferences:

Capilla-Perez L., Solier V., Portemer V., Chambon A., Hurel A., Christophorou N., Vezon D., Grelon M., Mercier R.. Description of new Arabidopsis thaliana mutants with defects in crossover number and distribution. EMBO Meiosis Meeting 2019 (poster)

Tourrette E., Falque M., Martin O. C. Unleashing genetic diversity by increased meiotic recombination: an in silico benchmark. DuPont Plant Sciences Symposia series: "Genetic Diversity: a Cornerstone of Plant Breeding", Paris (France), September 2017 (poster)

Tourrette E., Falque M., Martin O. C. Unleashing genetic diversity by increased meiotic recombination: an in silico benchmark. Plant and Animal Genome Conference, San Diego (USA), January 2018 (poster)

Tourrette E., Falque M., Martin O. C. Unleashing genetic diversity by increased meiotic recombination: an in silico benchmark. Maize Meeting, Saint-Malo (France), March 2018 (poster)

Tourrette E., Falque M., Martin O. C. Unleashing genetic diversity by increased meiotic recombination: an in silico benchmark. Eucarpia Biometrics, Ghent (Belgium), September 2018 (talk)

Tourrette E., Falque M., Martin O. C. Using increased recombination to accelerate genomic selection programs. Eucarpia Maize and Sorghum, Freising (Germany), October 2019 (talk)