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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Institutions

SPS - Saclay Plant Sciences

Intracellular anion dynamics (IntraDyn)

Coordinator: Alexis De Angeli

PhD project selected in 2014 – Person recruited: Elsa Demes-Causse

Ion transport across biological membranes is a fundamental process of every living cell that is involved in, for example, nutrition, signalling and in generating membrane potentials. The transport of solutes across membrane is controlled by specialised membrane proteins named transporters. Transporters are divided in two active and passive transporters, depending on the energetic of the process they catalyse. The separation between active and passive transporters became blurry after the discovery that within the same protein family, the CLC (Chloride Channel) family, different members were either active either passive transporters. This finding raised several questions about the structural determinants separating the two transporters types. In the model plant Arabidopsis thaliana there are seven members of the CLC family localised in intracellular membranes. The A. thaliana CLCs are involved in important physiological processes like nitrate storage, abiotic stress tolerance and stomata movements generating anion fluxes across intracellular membranes.  Despite their importance the functional characteristics of the majority of the Arabidopsis CLCs are unidentified. Moreover, in plant cells the dynamic of intracellular anion fluxes during cellular processes are largely unknown despite their fundamental role in in plant nutrition, salt stress tolerance and the regulation of stomata aperture. The present project  has two aims: i) characterising the functional characteristics of A. thaliana CLCs using an electrophysiological approach; ii) understanding the dynamic of intracellular anion fluxes in Arabidopsis cells using biosensors. The combination of the results will be a major step in understanding intracellular anion physiology.


Eisenach C., De Angeli A. (2017). Ion Transport at the Vacuole during Stomatal Movements. Plant Physiology 174(2): 520-530.

Communications in conferences:

- EMBO/FEBS Lecture"Ion channels and Transporters" Course 2017, Erice Italy  (Alexis De Angeli)

- EPSR, Barcelona Spain (Elsa DEMES)

- 6th Biosensor meeting, Orsay France, Alexis De angeli  (2016)