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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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SPS - Saclay Plant Sciences

Impact of the chromatine structure on meiotic recombination in Arabidopsis thaliana (Chromarec)

Coordinator: Christine Mezard

Post-doc project selected in 2014 – Person recruited: Nicolas Christophorou

Meiotic recombination is at the heart of the life cycle of all sexual eukaryotes. It ensures the faithful segregation of chromosomes and allelic reshuffling over generations. Remarkably, in almost all species, the distribution of crossovers (COs) is not homogeneous along chromosomes: domains with high CO rates alternate with domains where CO rates are significantly lower than the genome-wide average. The origin of such heterogeneity is still poorly understood but several lines of evidence point towards chromatin structure and chromosome dynamics issues. Within Chromarec, we have shown that in the axr1 mutant of Arabidopsis thaliana, the number of meiotic COs was not changed but their distribution along the chromosomes was dramatically altered. Indeed the COs were custered at the telomeric ends whereas a large central region was devoid of COs. In parallel, DNA of this region without recombination was heavily hypermethylated. We are looking at the underlying mechanisms of this abnormal DNA methylation and deciphering the correlation between DNA methylation and CO positioning. In parallel, we have set up a 3D fish technique to follow the dynamic of chromosomes during meiosis.


Manuscripts in preparation.

Communications in conferences:

Poster at the Gordon conference  "Meiosis", june 2016.

Talk (invited speaker) at the Plant Genome Stabiliy and Change meeting, Kanagawa, Japon