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AATTOL Characterization of the molecular bases for tolerance to African animal trypanosomosis: conjoint analysis of transcriptomas of the bovine host and parasite

AATTOL Characterization of the molecular bases for tolerance to African animal trypanosomosis: conjoint analysis of transcriptomas of the bovine host and parasite
© CIRAD David Berthier
African animal trypanosomosis, a disease due to blood parasites transmitted by the tsé-tsé fly, is a major obstacle for the development of cattle breeding in the humid and subhumid tropics of Africa, due to high mobidity and mortality that it causes. Only a few local bovine breeds are tolerant to the disease and remain productive in endemic zones. But, due to their small size, they are progressively crossbred with zebus and European sensitive breeds.

The objectives of the AATTOL project is to characterize the molecular bases of tolerance to this serious parasitic disease which affects livestock and to improve our knowledge of host-parasite interactions. The use of genetic diversity of bovine breeds may help control the disease, while associating the "trypanotolerance" to a higher level of animal production while decreasing the cost of teatment, its negative effects on the environment and the circulation of the pathogenic agent.

In addition, the characterization of the molecular bases of an efficient immune response could allow developing adapted control methods, based on the use of new medicine or the development of an innovative "anti-disease" vaccine, aimed at the key molecules of the parasite.

This knowlede will benefit farming in Africa but also more generally, our knowledge of animal adaptation to infectious diseases. This knowledge will interest  the parasitologist community who works on trypanosomosis biology, whether they be responsible for fighting animal trypanosomosis or sleeping sickness in men.

Partners

This project is financed by the Agence Nationale de la Recherche (ANR-2011-JSV6-001 01)