Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal LogoPREMIUM LogoEU



PREMIUM’s results disseminated through the publication in scientific journals are presented here below.



Content and link with WP, tasks


Fonseca, F., Pénicaud, C. Tymczyszyn, E.E., Gomez-Zavaglia, A., Passot, S. 2019. Factors influencing the membrane fluidity and the impact on production of lactic acid bacteria starters. Applied Microbiology and Biotechnology 103(17):6867–6883.


Invited mini-review on the state of the current understanding of stabilization mechanisms related to membrane properties, therefore in full in WP4 and also the link of membrane properties and particularly membrane fluidity to the production conditions (also related to WP3). WP4, WP3


Martins, G.N., Ureta, M.M., Tymczyszyn, E.E., Castilho, P.C.,  Gómez-Zavaglia, A. 2019. Technological Aspects of the Production of Fructo and Galacto-Oligosaccharides. Enzymatic Synthesis and Hydrolysis. Frontiers in Nutrition 6:78.


Invited review about the state of the art of the production of FOS and GOS, by synthesis and hydrolysis. WP2


Meneghel, J., Kilbride, P., Morris, J.G., Fonseca, F. 2019. Physical events occurring during the cryopreservation of immortalized human T cells. PLoS ONE 14(5): e0217304.

Asymptote, INRA

Article reporting on the intracellular glass transition temperature of Jurkat cells (an immortalized human T cell line) by DSC. This provides i) a better understanding of the behavior of mammalian cells during freezing and ii) is essential for optimizing cryopreservation protocols of mammalian cells. Such optimized protocols being used within WP5 when screening FOS/GOS as new cryoprotectants for mammalian cells. WP4, WP5


Girardeau, A., Puentes, C., Keravec, S., Peteuil, P., Tréléa, C., Fonseca, F. 2019. Influence of culture conditions on the technological properties of Carnobacterium maltaromaticum CNCM I-3298 starters. Journal of Applied Microbiology, 126: 1468-1479.

INRA, APT, Cryolog

Article reporting on the mapping of Carnobacterium maltaromaticum physiological states in pilot production conditions. This study was necessary for identifying relevant production conditions for studying preservation processes in WP3 and preservations mechanisms in WP4. WP3, WP4


Ghibaudo, F., Gerbino, E., Hugo, A., Simões, M.G., Alves, P., Costa, B., Campodall´Orto, V., Gómez-Zavaglia, A., Simões, P.N. 2018. Development and characterization of iron-pectin beads as a novel system for iron delivery to intestinal cells. Colloids and Surfaces B: Biointerfaces 170: 538-543.


Article related with the physical characterization of encapsulating materials. WP2, WP3


Romano, N., Araujo-Andrade, C., Lecot, C., Mobili, P., Gómez-Zavaglia, A. 2018. Infrared spectroscopy as an alternative methodology to evaluate the effect of structural features on the physical-chemical properties of inulins. Food Research International, 109(2018): 223–231.


Article that involves the physical and chemical properties determination of amorphous and crystalline inulins (raw polysaccharide used to obtain FOS by hydrolysis), using WAXS, DSC, FTIR and multivariate analysis. WP2


Simões, M.G., Hugo, A., Alves, P., Pérez, P.F., Gómez-Zavaglia, A., Simões, P.N. 2018. Long term stability and interaction with epithelial cells of freeze-dried pH-responsive liposomes functionalized with cholesterol-poly(acrylic acid). Colloids and Surfaces B-Biointerfaces, 164: 50-57.


Article related with experimental set up of methods included in PREMIUM (leakage experiments, work with eukaryotic cells). WP4

Article's figure

[Review article] Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges

Recently published review article in the journal Applied Microbiology and Biotechnology on the functionalities, applications and production stages of...
Read more