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Pr Bruno Vergès, responsable de l’équipe

Service Endocrinologie, Diabétologie et Maladies Métaboliques
Hôpital du Bocage
2 Bd Maréchal de Lattre de Tassigny
21000 Dijon

Approche spécifique de la thématique

• Dosages biologiques spécialisés (protéines impliquées dans le métabolisme lipidique, composition membranaires en acides gras)
• Etudes morphologiques chez l’Homme, en particulier estimation du contenu en graisse hépatique par spectroscopie protonique
• Etudes in vitro sur coupes de foie
• Etudes in vivo sur modèles animaux de diabète de type 2.

Publications récentes dans la thématique Nutrition et Cancer

• Legris P, Vaillard L, Nonciaux C, Hourdain P, Taroux M, Petit JM, Vergès B, Bouillet B. Diabetes is not associated with COVID-19-related mortality in older institutionalized people. Diabetes Metab. 2021 Jan 27:101235. [Epub ahead of print] [Résumé PubMed PMID 33515718]

• Vergès B, Duvillard L, Pais de Barros JP, Bouillet B, Baillot-Rudoni S, Rouland A, Petit JM, Degrace P, Demizieux L. Liraglutide increases the catabolism of apolipoprotein B100-containing lipoproteins in patients with type 2 diabetes and reduces proprotein convertase Subtilisin/Kexin type 9 expression. Diabetes Care. 2021 Apr;44(4):1027-37. [Résumé PubMed PMID 33531418]

• Alexia Rouland, Benjamin Bouillet, Pauline Legris, Isabelle Simoneau, Jean-Michel Petit, Bruno Vergès. Successful Control of Hypoglycemia with Pasireotide LAR in a Patient with Inappropriate Insulin Secretion. Clin Pharmacol. 2021 Feb 5;13:33-37. [Résumé PubMed PMID 33574715]

• Vergès B, Pignol E, Rouland A, Bouillet B, Baillot-Rudoni S, Quilot E, Djeffal A, Petit JM.Glycemic variability assessment with a 14-day continuous glucose monitoring system: when and how long to measure MAGE (Mean Amplitude of Glucose Excursion) for optimal reliability? J Diabetes Sci Technol. 2021 Feb 10:1932296821992060. [Epub ahead of print] [Résumé PubMed PMID 33515718]

• Wargny M, Potier L, Gourdy P, Pichelin M, Amadou C, Benhamou PY, Bonnet JB, Bordier L, Bourron O, Chaumeil C, Chevalier N, Darmon P, et al. Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study.Diabetologia. 2021 Apr;64(4):778-94. [Résumé PubMed PMID 33599800]

• Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Rossing P, Kolkhof P, Nowack C, Schloemer P, Joseph A, Filippatos G; FIDELIO-DKD Investigators. Effect of finerenone on chronic kidney disease outcomes in Type 2 diabetes N Engl J Med. 2020 Dec 3;383(23):2219-29. [Résumé PubMed PMID 33264825]

• Smati S, Tramunt B, Wargny M, Caussy C, Gaborit B, Vatier C, Vergès B, Ancelle D, Amadou C, Bachir LA, Bourron O, Coffin-Boutreux C, et al. Relationship between obesity and severe COVID-19 outcomes in patients with type 2 diabetes: Results from the CORONADO study. Diabetes Obes Metab. 2021 Feb;23(2):391-403. [Résumé PubMed PMID 33051976]

• Vergès B. Cardiovascular disease in type 1 diabetes: A review of epidemiological data and underlying mechanisms. Diabetes Metab. 2020 Nov;46(6):442-9. [Résumé PubMed PMID 32998054]

• Wargny M, Gourdy P, Ludwig L, Seret-Bégué D, Bourron O, Darmon P, Amadou C, Pichelin M, Potier L, Thivolet C, Gautier JF, Hadjadj S, Cariou B; CORONADO investigators.Type 1 diabetes in people hospitalized for COVID-19: new insights from the CORONADO study. Diabetes Care. 2020 Nov;43(11):e174-e177. [Résumé PubMed PMID 32847826]

• Valensi P, Belle EV, Cosson E, Emmerich J, Prevost G, Ferrières J, Sultan A, Ernande L, Rouzet F, Marcadet D, Mousseaux E, Boccara F, et al. Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus. Diabetes Metab. 2021 Mar;47(2):101185. [Résumé PubMed PMID 32846201]

• Vergès B, Rouland A, Baillot-Rudoni S, Brindisi MC, Duvillard L, Simoneau I, Legris P, Petit JM, Bouillet B. Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients. J Diabetes Investig. 2021 Apr;12(4):619-624. [Résumé PubMed PMID 32767822]

• Meloni M, Bouillet B, Ahluwalia R, Lüdemann C, Sánchez-Ríos JP, Iacopi E, Lazaro-Martinez JL. Fast-track pathway for diabetic foot ulceration during COVID-19 crisis: A document from International Diabetic Foot Care Group and D-Foot International. Diabetes Metab Res Rev. 2021 Mar;37(3):e3396. [Résumé PubMed PMID 32804425]

• Gallo A, Charriere S, Vimont A, Chapman MJ, Angoulvant D, Boccara F, Cariou B, Carreau V, Carrié A, Bruckert E, Béliard S; French REgistry of Familial hypERCHOLesterolemia (REFERCHOL) investigators. SAFEHEART risk-equation and cholesterol-year-score are powerful predictors of cardiovascular events in French patients with familial hypercholesterolemia. Atherosclerosis. 2020 Aug;306:41-49. [Résumé PubMed PMID 32688103]

• Majidi F, Martino S, Kondakci M, Antke C, Haase M, Chortis V, Arlt W, Ronchi CL, Fassnacht M, Laurent C, Petit JM, Casasnovas O, et al. Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study. Eur J Endocrinol. 2020 Oct;183(4):453-62. [Résumé PubMed PMID 32567556]

• Roger C, Buch C, Muller T, Leemput J, Demizieux L, Passilly-Degrace P, Cinar R, Iyer MR, Kunos G, Vergès B, Degrace P, Jourdan T. Simultaneous inhibition of peripheral CB1R and iNOS mitigates obesity-related dyslipidemia through distinct mechanisms. Diabetes. 2020 Oct;69(10):2120-2132. [Résumé PubMed PMID 32680936]

• Besnard P, Christensen JE, Bernard A, Simoneau-Robin I, Collet X, Vergès B, Burcelin R. Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients. Acta Diabetol. 2020 Dec;57(12):1445-51. [Résumé PubMed PMID 32676702]

• Petit JM, Goueslard K, Chauvet-Gelinier JC, Bouillet B, Vergès B, Jollant F, Quantin C. Association between hospital admission for ketoacidosis and subsequent suicide attempt in young adults with type 1 diabetes. Diabetologia. 2020 Sep;63(9):1745-52. [Résumé PubMed PMID 32642808]

• Bouillet B, Gautier T, Denimal D, Samson M, Masson D, Pais de Barros JP, Maquart G, Xolin M, Grosfeld A, Dalle H, Vergès B, Moldes M, Fève B. Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration: a proof of concept. Eur J Endocrinol. 2020 Sep;183(3):297-306. [Résumé PubMed PMID 32570209]

• Quilot E, Petit JM, Vergès B, Bouillet B. Are older patients with diabetes still being overtreated in French long-term care homes? Age Ageing. 2020 Aug 24;49(5):878-82. [Résumé PubMed PMID 32457990]
• Vergès B.Dyslipidemia in Type 1 Diabetes: A Masked Danger. Trends Endocrinol Metab. 2020 Jun;31(6):422-34. [Résumé PubMed PMID 32217073]

• Bouillet B, Crevisy E, Baillot-Rudoni S, Gallegarine D, Jouan T, Duffourd Y, Petit JM, Vergès B, Callier P. Whole-exome sequencing identifies the first French MODY 6 family with a new mutation in the NEUROD1 gene. Diabetes Metab. 2020 Oct;46(5):400-2. [Résumé PubMed PMID 32184107]

• Guillot A, Buch C, Jourdan T. Kupffer Cell and Monocyte-Derived Macrophage Identification by Immunofluorescence on Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse Liver Sections. Methods Mol Biol. 2020;2164:45-53. [Résumé PubMed PMID 32607882]

• Rouland A, Buffier P, Petit JM, Vergès B, Bouillet B. Thyroiditis: What's new in 2019? Rev Med Interne. 2020 Jun;41(6):390-5. [Résumé PubMed PMID 32107053]

• Mouillot T, Rizk M, Pais de Barros JP, Gilloteau A, Busson A, Bernard-Chabert B, Thiefin G, Barraud H, Bronowicki JP, Richou C, Di Martino V, Doffoel M, et al. Fatty acid composition of the erythrocyte membrane and risk of hepatocellular carcinoma in cirrhotic patients. Aliment Pharmacol Ther. 2020 Nov;52(9):1503-15. [Résumé PubMed PMID 32780481]

• Li LY, Li JM, Ning LJ, Lu DL, Luo Y, Ma Q, Limbu SM, Li DL, Chen LQ, Lodhi IJ, Degrace P, Zhang ML, Du ZY. Mitochondrial fatty acid β-Oxidation inhibition promotes glucose utilization and protein deposition through energy homeostasis remodeling in fish. J Nutr. 2020 Sep 1;150(9):2322-2335. [Résumé PubMed PMID 32720689]

• Rouland A, Chauvet-Gelinier JC, Sberna AL, Crevisy E, Buffier P, Mouillot T, Petit JM, Vergès B. Personality types in individuals with type 1 and type 2 diabetes. Endocr Connect. 2020 Feb 1;9(3):254-60. [Résumé PubMed PMID 32101526]

• Capehorn MS, Catarig AM, Furberg JK, Janez A, Price HC, Tadayon S, Vergès B, Marre M. Efficacy and safety of once-weekly semaglutide 1.0mg vs once-daily liraglutide 1.2mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10). Diabetes Metab. 2020 Apr;46(2):100-9. [Résumé PubMed PMID 31539622]

• Fritzen K, Basinska K, Stautner C, Braun KF, Rubio-Almanza M, Nicolucci A, Kennon B, Vergès B, Hosny Y, Schnell O. Budget impact of improved diabetes management by utilization of glucose meters with a color-range indicator-comparison of five European healthcare systems. J Diabetes Sci Technol. 2020 Mar;14(2):262-70. [Résumé PubMed PMID 31387385]

• Laurent C, Aho Glele LS, Lazzarotti A, Petit JM, Vergès B, Bouillet B. Who is at risk for drug-drug interactions in type 2 diabetic patients? Presse Med. 2019 Dec;48(12):1576-8. [Résumé PubMed PMID 31761604]

• Bouillet B, Rouland A, Petit JM, Vergès B. A low-carbohydrate high-fat diet initiated promptly after diagnosis provides clinical remission in three patients with type 1 diabetes. Diabetes Metab. 2020 Nov;46(6):511-3. [Résumé PubMed PMID 31301353]

• Chauvet-Gélinier JC, Mosca-Boidron AL, Lemogne C, Ragot S, Forestier N, Callegarin D, Allard C, Rebaï A, Bouillet B, Ponavoy E, et al. Type A competitiveness traits correlate with downregulation of c-Fos expression in patients with type 1 diabetes. Diabetes Metab. 2019 Dec;45(6):582-5. [Résumé PubMed PMID 30476653]

• Ruilope LM, Agarwal R, Anker SD, Bakris GL, Filippatos G, Nowack C, Kolkhof P, Joseph A, Mentenich N, Pitt B; FIGARO-DKD study investigators..Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial. Am J Nephrol. 2019;50(5):345-56. [Résumé PubMed PMID 31665733]

• Bakris GL, Agarwal R, Anker SD, Pitt B, Ruilope LM, Nowack C, Kolkhof P, Ferreira AC, Schloemer P, Filippatos G; on behalf of the FIDELIO-DKD study investigators; FIDELIO-DKD study investigators. Design and baseline characteristics of the finerenone in reducing kidney failure and disease progression in diabetic kidney disease trial. Am J Nephrol. 2019; 50(5):333-44. [Résumé PubMed PMID 31655812]

• Guillot A, Ren T, Jourdan T, Pawlosky RJ, Han E, Kim JS, Zhang L, Koob GF, Gao B. Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking. Proc Natl Acad Sci USA 2019; 116: 25974-81. [Résumé PubMed PMID 31792171]

• Li JM, Li LY, Zhang YX, Jiang ZY, Limbu SM, Qiao F, Degrace P, Chen LQ, Zhang ML, Du ZY. Functional differences between l- and d-carnitine in metabolic regulation evaluated using a low-carnitine Nile tilapia model. Br J Nutr. 2019 Sep 28;122(6):625-38. [Résumé PubMed PMID 32124711]

• Capehorn MS, Catarig AM, Furberg JK, Janez A, Price HC, Tadayon S, Vergès B, Marre M. Efficacy and safety of once-weekly semaglutide 1.0mg vs once-daily liraglutide 1.2mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10). Diabetes Metab. 2020 Apr;46(2):100-9. [Résumé PubMed PMID 31539622]

• Brindisi MC, Brondel L, Meillon S, Barthet S, Grall S, Fenech C, Liénard F, Schlich P, Astruc K, Mouillot T, Jacquin-Piques A, Leloup C, et al. Proof of concept: Effect of GLP-1 agonist on food hedonic responses and taste sensitivity in poor controlled type 2 diabetic patients. Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2489-94. [Résumé PubMed PMID 31405666]

• Rosenzweig JL, Bakris GL, Berglund LF, Hivert MF, Horton ES, Kalyani RR, Murad MH, Vergès BL. Primary prevention of ASCVD and T2DM in patients at metabolic risk: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2019 Jul 31;jc.2019-01338. [Epub ahead of print] [Résumé PubMed PMID 31365087]

• Bouillet B, Gautier T, Rouland A, Duvillard L, Petit JM, Lagrost L, Vergès B. Plasma apolipoprotein C1 concentration is associated with plasma triglyceride concentration but not with visceral fat and liver fat content in people with type 1 diabetes. Acta Diabetol. 2019 Oct;56(10):1155-1157. [Résumé PubMed PMID 31119457]

• Nguyen M, Denimal D, Dargent A, Guinot PG, Duvillard L, Quenot JP, Bouhemad B. Plasma renin concentration is associated with hemodynamic deficiency and adverse renal outcome in septic shock., Shock. 2019 Oct;52(4):e22-e30. [Résumé PubMed PMID 30407370]

• Bernard A, Ancel D, Passilly-Degrace P, Landrier JF, Lagrost L, Besnard P. A chronic LPS-induced low-grade inflammation fails to reproduce in lean mice the impairment of preference for oily solution found in diet-induced obese mice. Biochimie 2019 Apr; 159:112-21. [Résumé PubMed PMID 30102932]

• Michiels Y, Bugnon O, Chicoye A, Dejager S, Moisan C, Allaert FA, Hunault C, Romengas L, Méchin H, Vergès B. Impact of a community pharmacist-delivered information program on the follow-up of type-2 diabetic patients: A cluster randomized controlled study. Adv Ther. 2019 Jun;36(6):1291-303. [Résumé PubMed PMID 31049873]

• Rey R, Chauvet-Gelinier JC, Suaud-Chagny MF, Ragot S, Bonin B, d'Amato T, Teyssier JR. Distinct expression pattern of epigenetic machinery genes in blood leucocytes and brain cortex of depressive patients. Mol Neurobiol. 2019;56(7):4697-707. [Résumé PubMed PMID 30377985]

• Fiot E, Zénaty D, Boizeau P, Haignere J, Dos Santos S, Léger J; French Turner Syndrome Study Group. X chromosome gene dosage as a determinant of congenital malformations and of age-related comorbidity risk in patients with Turner syndrome, from childhood to early adulthood. Eur J Endocrinol. 2019 Jun 1;180(6):397-406. [Résumé PubMed PMID 30991358]

• Bouillet B, Gautier T, Terriat B, Lagrost L, Verges B, Petit JM. CETP activity is not associated with carotid intima-media thickness in patients with poorly controlled type 2 diabetes. Acta Diabetol. 2019 Jul;56(7):749-754. [Résumé PubMed PMID 30980187]

• Sánchez-Ríos JP, García-Klepzig JL, Manu C, Ahluwalia R, Lüdemann C, Meloni M, Lacopi E, De Buruaga VR, Bouillet B, Vouillarmet J, Lázaro-Martínez JL, Van Acker K. Referral of patients with diabetic foot ulcers in four European countries: patient follow-up after first GP visit. J Wound Care. 2019 Aug 1;28(Sup8):S4-S14. [Résumé PubMed PMID 31393783]

• Fritzen K, Basinska K, Rubio-Almanza M, Nicolucci A, Kennon B, Vergès B, Zakrzewska K, Schnell O. Pan-European economic analysis to identify cost savings for the health care systems as a result of integrating glucose monitoring based telemedical approaches into diabetes management. J Diabetes Sci Technol. 2019 Nov;13(6):1112-22. [Résumé PubMed PMID 30917691]

• Liu J, Godlewski G, Jourdan T, Liu Z, Cinar R, Xiong K, Kunos G. Cannabinoid-1 receptor antagonism improves glycemic control and increases energy expenditure via Sirt1/mTORC2 and AMPK signaling. Hepatology 2019 ; 69:1535-48. [Résumé PubMed PMID 30506571]

• Godlewski G, Cinar R, Coffey NJ, Liu J, Jourdan T, Mukhopadhyay B, Chedester L, Liu Z, Osei-Hyiaman D, Iyer MR, Park JK, Smith R, et al. Targeting peripheral CB1 receptors reduces ethanol intake via a gut-brain axis. Cell metabolism 2019, 29: 1320-33.e8. [Résumé PubMed PMID 31105045]

• Benalia M, Zeller M, Mouhat B, Guenancia C, Yameogo V, Greco C, Yao H, Maza M, Vergès B, Cottin Y. Glycaemic variability is associated with severity of coronary artery disease in patients with poorly controlled type 2 diabetes and acute myocardial infarction. Diabetes Metab. 2019 Oct;45(5):446-52. [Résumé PubMed PMID 30763700]

• Guerci B, Charbonnel B, Gourdy P, Hadjadj S, Hanaire H, Marre M, Vergès B. Efficacy and adherence of glucagon-like peptide-1 receptor agonist treatment in patients with type 2 diabetes mellitus in real-life settings. Diabetes Metab. 2019 Dec;45(6):528-35. [Résumé PubMed PMID 30677504]

• Chauvet-Gelinier JC, Roussot A, Cottenet J, Brindisi MC, Petit JM, Bonin B, Vergès B, Quantin C. Depression and obesity, data from a national administrative database study: Geographic evidence for an epidemiological overlap. PLoS One. 2019 Jan 8;14(1):e0210507. [Résumé PubMed PMID 30620759]

• Chauvet-Gélinier JC, Mosca-Boidron AL, Lemogne C, Ragot S, Forestier N, Callegarin D, Allard C, Rebaï A, Bouillet B, Ponavoy E, Simoneau I, Petit JM. Type A competitiveness traits correlate with downregulation of c-Fos expression in patients with type 1 diabetes. Diabetes Metab. 2019 Dec;45(6):582-5. [Résumé PubMed PMID 30476653]

• Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, et al. Dapagliflozin and cardiovascular outcomes in Type 2 diabetes. N Engl J Med. 2019 Jan 24;380(4):347-57. [Résumé PubMed PMID 30415602]

• Rouland A, Fourmont C, Sberna AL, Aho Glele LS, Mouillot T, Simoneau I, Vergès B, Petit JM, Bouillet B. Malnutrition in type 2 diabetic patients does not affect healing of foot ulcers. Acta Diabetol. 2019 Feb;56(2):171-6. [Résumé PubMed PMID 30284047]

• Vergès B, Patois-Vergès B, Goueslard K, Cottenet J, Nguyen A, Tatulashvili S, Blonde MC, Quantin C. High efficacy of screening for diabetes and prediabetes in cardiac rehabilitation after an acute coronary syndrome (ACS). The REHABDIAB study. Diabetes Metab. 2019 Jan;45(1):79-82. [Résumé PubMed PMID 28669513]