Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo TULIP Nouveau bandeau tutelles EN


Brenda Winkel « Visiting Scientist » seminar

01.29.2020 - Marc-Ridet conference room (INRAE Auzeville campus)

Brenda Winkel « Visiting Scientist » seminar
Brenda Winkel will give a seminar « Watching the clock: Evidence that flavonoids affect the circadian circuitry of plants » on wednesday january 29th at 11:00 in the Marc-Ridet conference room (INRAE Auzeville campus)

Over the past 25 years the Winkel laboratory has helped establish the flavonoid pathway as a model for studying the macromolecular and intracellular organization of plant metabolism. They were the first to demonstrate direct protein interactions among flavonoid enzymes and also uncovered the unexpected localization of flavonoid enzymes in the nucleus.  Most recently, they showed that the entry-point enzyme, chalcone synthase (CHS), interacts with components of the histone remodeling machinery that may offer a new explanation for the connection between flavonoid enzymes and defense.  

Winkel photo

To further explore the potential impact of CHS on gene expression, an RNA-seq dataset was generated for an Arabidopsis tt4 mutant line, which lacks the enzyme and is devoid of flavonoids.  This experiment identified numerous transcripts with altered levels in tt4 seedlings.  Surprisingly, a substantial number of these encode components of the core circadian clock, including the key transcriptional regulators, CCA1 and TOC1.  Analysis of CCA1p::luciferase and TOC1p::luciferase reporter constructs further showed that the amplitude, but not the phase, of the circadian cycle is altered in CHS-deficient seedlings.  Similar effects were observed for a tt7 mutant allele, which affects an intermediate step in flavonoid metabolism, implicating dihydroxy flavonoids rather than the CHS enzyme in modulation of the clock.  Current experiments are aimed at understanding the mechanisms underlying this intriguing newly-discovered connection between flavonoids and the circadian circuitry in plants, which has recently also been reported in animal systems.

Bio: Brenda Winkel is a Professor and former Head of Biological Sciences at Virginia Tech in the U.S. She is currently on Research Leave as a TULIP Visiting Scientist with Elodie Gaulin in the IPM team of Bernard Dumas.