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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal JPI


Project coordinator




Dr Cécile Gladine investigates the relationships between diet, oxylipins and cardiometabolic health combining metabolomics of oxylipins with more targeted approaches of molecular and cell biology.


2008-2009:       Post-doctoral research at the AgResearch Institute (Palmerston North, NZ), Food Nutrition Genomic team (Dr Nicole Roy)

2003-2006:       Ph.D. in Nutrition, Metabolism and Biochemistry, University School of Medicine, Clermont-Ferrand, France (French Research Ministry grant)

2002-2003:       M.Sc. in Nutrition and Food Sciences, University School of Medicine, Clermont-Ferrand, France

2001-2002:       M.Sc. in Nutrition of Developing Countries, University School of Sciences, Montpellier, France

1998-2001:        B.Sc. Applied Biosciences and Chemistry, Robert Gordon University, Aberdeen, Scotland.


2007-Present:   Researcher, INRA, UMR 1019, Human Nutrition (Permanent position)

2008-2009:       Postdoctoral Research Fellow, AgResearch Institute, Food Nutrition Genomic team

2006-2007:       Teacher & Research Assistant, University School of Medicine, Clermont-Ferrand, France

2003-2006:       Doctoral research, University School of Medicine, Clermont-Ferrand, France (French Research Ministry grant)


Bosviel R, Joumard-Cubizolles L, Chinetti-Gbaguidi G, Bayle D, Copin C, Hennuyer N, Duplan I, Staels B, Zanoni G, Porta A, Balas L, Galano JM, Oger C, Mazur A, Durand T, Gladine C. (2017). DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: putative mechanisms through PPAR activation. Free Radical Biology and Medicine, 103, 146-154. DOI : 10.1016/j.freeradbiomed.2016.12.018

Gladine C, Newman JW, Durand T, Pedersen TL, Galano JM, Demougeot C, Berdeaux O, Pujos-Guillot E, Mazur A, Comte B. Lipid Profiling Following Intake of the Omega 3 Fatty Acid DHA Identifies the Peroxidized Metabolites F4-Neuroprostanes as the Best Predictors of Atherosclerosis Prevention. PLoS ONE 2014 9(2): e89393. doi:10.1371/journal.pone.0089393

Galano JM, Lee JCY, Gladine C, Comte B, Le Guennec JY, Oger C, Durand T. Oxygenated cyclic metabolites of n-3 polyunsaturated fatty acids and adrenic acid: Biomarkers and second messengers of oxidative stress. Biochim Biophys Acta. 2014: S1388-1981(14)00232-7. doi: 10.1016/j.bbalip.2014.11.004.

Gladine C, Joumard-Cubizolles L, Chinetti G, Bayle D, Copin C, Hennuyer N, Staels B, Zanoni G, Porta A, Galano JM, Oger C, Durand T, Mazur A. Neuroprostanes, produced by free-radical mediated peroxidation of DHA, inhibit the inflammatory response of human macrophages. FRBM. 2014; 75, Supplement 1: S15

Gladine C, Zmojdzian M, Joumard-Cubizolles L, Verny MA, Comte B, Mazur A. The omega-3 fatty acid docosahexaenoic acid favourably modulates the inflammatory pathways and macrophage polarization within aorta of LDLR-/- mice. Genes&Nutr. 2014, 9, 5:424, DOI: 10.1007/s12263-014-0424-4

Gladine C, Combe N, Vaysse C, Pereira B, Huertas A, Salvati S, et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim’Oils randomized intervention trial. J Nutr Biochem. 2013; 24:544-549.