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Oxygenate

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Welcome to the OXYGENATE portal!

OXYGENATE "Oxylipins signature to monitor the cardiometabolic status and its response to dietary intervention"

The OXYGENATE project aims to uncover and validate the oxylipin signatures reflecting the trajectory from health to cardiometabolic syndrome and its relationships with diet

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(https://www.youtube.com/watch?v=aLIxhBUTI1M&t=2s)

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The OXYGENATE Project is supported by the EU Joint Programming Initiative A Healthy Diet for a Healthy Life through participating organization's local funding agencies.
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What are oxylipins?
Oxylipins refers to a superclass of lipid mediators produced from oxygenation of polyunsaturated fatty acids. They include the prostanoids produced by cyclooxygenases; leukotrienes, resolvins, hepoxilins and mid-chain hydroxy-FA generated by lipoxygenases, epoxy-FA and omega-terminal hydroxy-FA produced by several cytochrome P450 monooxygenases as well as iso/neuroprostanes resulting from the free-radical-mediated oxidation of PUFAs.
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Cardiometabolic syndrome
The cardiometabolic syndrome is a progressive condition encompassing a constellation of metabolic abnormalities. These include abdominal obesity, insulin-resistant glucose metabolism, dyslipidaemia and increased blood pressure.
These abnormalities are risk factors for cardiometabolic diseases and in particular cardiovascular diseases which represent an enormous burden for health care with a cost for the EU economy estimated at more than €196 billion per year.
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Rational & Hypothesis
There is an urgent need to find reliable early biomarkers of the cardiometabolic syndrome allowing intervention before irreversible damage develops while assessing the efficacy of nutritional prevention.
Oxylipins are involved in the homeostasis of various process related to the cardiometabolic status and there is a consistent link between diet, oxylipins and cardiometabolic dysregulations
Comprehensive oxylipin profiling could identify reliable early biomarker patterns of the cardiometabolic syndrome and will provide a new tool for assessing the efficacy of dietary interventions.
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Methods
Using an optimized targeted lipidomic approach and leveraging 2 independent prospective cohorts (i.e. the Polish PURE and the French NutriNet-Santé cohorts) and 2 whole-diet interventions (Shopus and iMAPS) we will identify and validate oxylipin signatures (i) differentiating individuals at different stages of CardMetS and with different dietary patterns and (ii) evolving consistently with dietary interventions affecting the cardiometabolic endpoints.