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The integrative approach of EPITREE includes 5 WorkPackages (WP):

• WP1 - Screening for candidate regions for epigenomic analysis - Leading Scientists: S. Maury (P1), J Tost (P6)
  • Selection of genotypes of poplar and oak for whole-genome bisulfite sequencing (WGBS)
• WP2 - Characterization of the extent of epigenomic variation in natural populations and its functional consequences - Leading Scientists: V Segura (P2), C. Plomion (P3)
  • Characterize the extent of epigenomic variation within natural populations of sessile oak and black poplar and to evaluate its functional consequences
• WP3 - Epigenomic plasticity in response to environmental constraints and its functional consequences - Leading Scientists: Regis Fichot (P1), G. Le Provost (P3)
  • Quantify the extent of G×E interactions for epigenomic, transcriptomic and phenotypic variation
  • Characterize G×E interactions through reaction norms and plasticity indices
• WP4 - Integrative analysis modelling the multiscale relationships between quantitative traits and their molecular determinants - Leading Scientists: Jérôme Salse (P4) and Christophe Ambroise (P5)
  • Develop statistical methods within a bioinformatics framework, to integrate heterogeneous data at different scales and to analyse their relevance for phenotype prediction
  • Integration of gene expression and methylation data
  • Impact of long-term evolution on the short-term adaptation of trees
• WP5 - Co-ordination and dissemination under the responsibility of P1
  • Scientific and administrative management
  • Dissemination
  • Teaching activities