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Dernière mise à jour : Mai 2018

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Belo GA, Cordeiro BF, Oliveira ER, Braga MP, da Silva SH, Costa BG, Martins FDS, Jan G, Le Loir Y, Gala-García A, Ferreira E, Azevedo V, do Carmo FLR. 2021. SlpB Protein Enhances the Probiotic Potential of L. lactis NCDO 2118 in Colitis Mice Model. Front Pharmacol. 12:755825.
doi: 10.3389/fphar.2021.755825.

Savassi B, Cordeiro BF, Silva SH, Oliveira ER, Belo G, Figueiroa AG, Alves Queiroz MI, Faria AMC, Alves J, da Silva TF, Campos GM, Esmerino EA, Rocha RS, Freitas MQ, Silva MC, Cruz AG, Vital KD, Fernandes SOA, Cardoso VN, Acurcio LB, Jan G, Le Loir Y, Gala-Garcia A, do Carmo FLR, Azevedo V. 2021. Lyophilized Symbiotic Mitigates Mucositis Induced by 5-Fluorouracil. Front Pharmacol.  12:755871.
doi: 10.3389/fphar.2021.755871


Brenda Silva Rosa da Luz, Aurélie Nicolas, Svetlana Chabelskaya, Vinícius De Rezende Rodovalho, Yves Le Loir, Vasco Ariston De Carvalho Azevedo, Brice Felden, Eric Guédon. 2021. Environmental plasticity of the RNA content of Staphylococcus aureus extracellular vesicles. Frontiers in Microbiology. 12:634226.
doi: 10.3389/fmicb.2021.634226

Bárbara Fernandes Cordeiro, Juliana Lima Alves, Giovanna A Belo, Emiliano Rosa Oliveira, Marina P Braga, Sara Heloisa Silva, Luisa Lemos Santos, Jonas T Guimarães, Ramon Silva, Ramon S Rocha, Gwénaël Jan, Yves Le Loir, Marcia Cristina Silva, Mônica Q Freitas, Erick A Esmerino, Alfonso Gala-García, Enio Ferreira, Ana Maria Caetano Faria, Adriano G Cruz, Vasco Ariston De Carvalho Azevedo, Fillipe Luiz Rosa do Carmo. 2021. Therapeutic effects of probiotic Minas Frescal cheese on the attenuation of ulcerative colitis in a murine model. Front. Microbiol. 12:623920.


Rezende Rodovalho V, da Luz BSR, Nicolas A, do Carmo FLR, Jardin J, Briard-Bion V, Jan G, Le Loir Y, de Carvalho Azevedo VA, Guedon E. 2020. Environmental conditions modulate the protein content and immunomodulatory activity of extracellular vesicles produced by the probiotic Propionibacterium freudenreichii. Appl Environ Microbiol. 2020 Dec 11:AEM.02263-20.
doi: 10.1128/AEM.02263-20.

Rabah H, do Carmo FLR, Carvalho RDO, Cordeiro BF, da Silva SH, Oliveira ER, Lemos L, Cara DC, Faria AMC, Garric G, Harel-Oger M, Le Loir Y, Azevedo V, Bouguen G, Jan G. 2020.Beneficial Propionibacteria within a Probiotic Emmental Cheese: Impact on Dextran Sodium Sulphate-Induced Colitis in Mice. Microorganisms. 2020 Mar 7;8(3):380.
doi: 10.3390/microorganisms8030380.

Castro-Oliveira L., Silva M.O., Carvalho R.D.O., Anchiêta A., Benevides L.J., Oliveira C.J.F., Jan G., Figueiredo H.C.P., Azevedo V.A.C. and Soares S.C.. 2020. Omics of probiotic bacteria: which features to seek? Genet. Mol. Res. 19(2): GMR18599
doi: 10.4238/gmr18599

Leite, EL; de Oliveira, AF; Do Carmo, FLR; Berkova, N; Barh, D; Ghosh, P; Azevedo, V. 2020 Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus. Anais da Academia Brasileira de Ciências  Volume: ‏ 92   Issue: ‏ suppl 2   Pages: ‏ e20201216   Article Number: e20201216

Vinícius de Rezende Rodovalho, Brenda Silva Rosa da Luz, Houem Rabah, Fillipe Luiz Rosa do Carmo, Edson Luiz Folador, Aurélie Nicolas, Julien Jardin, Valérie Briard-Bion, Hervé Blottière, Nicolas Lapaque, Gwenaël Jan, Yves Le Loir, Vasco Ariston De Carvalho Azevedo, Eric Guédon. 2020. Extracellular vesicles produced by the probiotic Propionibacterium freudenreichii CIRM-BIA 129 mitigate inflammation by modulating the NF-κB pathway. Front Microbiol. 11:1544.
doi: 10.3389/fmicb.2020.01544. eCollection 2020.

Tartaglia, Natayme Rocha; Nicolas, Aurelie; Rodovalho, Vinicius de Rezende; Luz, Brenda Silva Rosa da; Briard-Bion, Valerie; Krupova, Zuzana; Thierry, Anne; Coste, Francois; Burel, Agnes; Martin, Patrice; Jardin, Julien; Azevedo, Vasco; Le Loir, Yves; Guedon, Eric. 2020 Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome. Scientific reports 10(1): 8467.

Elma Lima Leite, Arthur Gautron, Martine Deplanche, Aurelie Nicolas, David Gilot, Vasco Azevedo, Petr Broz, Yves Le Loir, Nadia Berkova. 2020. Inflammasomes involvement in Staphylococcus aureus infection of human osteoblast-like cells. Cellular Microbiology 16:e13204.
doi: 10.1111/cmi.13204.

Houem Rabah, Fillipe Luiz Rosa do Carmo, Rodrigo Dias de Oliveira Carvalho, Barbara Fernandes Cordeiro,Sara Heloisa da Silva, Emiliano Rosa Oliveira, Luisa Lemos, Denise Carmona Cara, Ana Maria Caetano Faria, Gilles Garric, Marielle Harel-Oger, Yves Le Loir, Vasco Azevedo, Guillaume Bouguen, and Gwénaël Jan. 2020. Effect of probiotic Emmental cheese on DSS-induced colitis in mice and in a clinical pilot study. Microorganisms. 8(3):380.
doi: 10.3390/microorganisms8030380.8467


Imanishi I., A. Nicolas, A.-C. Barbosa Caetano, T. L. de Paula Castro, N. Rocha Tartaglia, R. Mariutti, E. Guédon, S. Even, N. Berkova, R. K. Arni, N. Seyffert, V. Azevedo, K. Nishifuji and Y. Le Loir. 2019. Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity. Scientific Reports. 9:16336 (limited access).

Breyner NM, Boas PBV, Fernandes G, de Carvalho RD, Rochat T, Michel ML, Chain F, Sokol H, de Azevedo M, Myioshi A, Azevedo VA, Langella P, Bermúdez-Humarán LG, Chatel JM. Oral delivery of Pancreatitis-Associated Protein by Lactococcus lactis displays protective effects in DNBS-induced colitis model and is able to modulate the composition of the microbiota. Environ Microbiol. 2019 Jul 19.
doi: 10.1111/1462-2920.14748.

Rosa do Carmo, F. L., Rabah H., Fernandes Cordeiro, B., da Silva, S. H., Miranda Pessoa, R., Antunes Fernandes, S. O., Nascimento Cardoso, V., Gagnaire, V., Deplanche, M., Savassi, B., Figueiroa, A., Rosa Oliveira, E., Fonseca, C. C., Alves Queiroz, M. I., Morais Rodrigues, N., de Cicco Sandes, S. H., Cantini Nunes, Á., Lemos, L., de Lima Alves, J., Caetano Faria, A. M., Ferreira, Ê., Le Loir, Y., Jan, G., Azevedo, V. 2019. Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy. Oncotarget. 10(68):7198-7219.
doi: 10.18632/oncotarget.27319. 

Flávia Figueira Aburjaile, Gwénaël Jan, Yves Le Loir, Vasco Azevedo and Rodrigo Dias de Oliveira Carvalho. 2019. Wild-Type and Genetically Improved Strains of Dairy Origin Probiotic as Potential Treatments for Intestinal Mucositis. Journal of Pharmacy and Pharmacology 7:177-186. doi: 10.17265/2328-2150/2019.04.004

Vasco Azevedo, Jean-Marc Chatel, Philippe Langella et Yves Le Loir, « Le laboratoire international associé Bact-Inflam, l’aboutissement de 17 années de collaboration France-Brésil », Histoire de la recherche contemporaine [En ligne], Tome VII N°2 | 2018, mis en ligne le 15 avril 2019. URL : ;
doi: 10.4000/hrc.2490.


Carvalho R, Vaz A, Pereira FL, Dorella F, Aguiar E, Chatel JM, Bermudez L, Langella P, Fernandes G, Figueiredo H, Goes-Neto A, Azevedo V. Gut microbiome modulation during treatment of mucositis with the dairy bacterium Lactococcus lactis and recombinant strain secreting human antimicrobial PAP. Sci Rep. 2018 Oct 10;8(1):15072.
doi: 10.1038/s41598-018-33469-w.

B.F. Cordeiro, E.R. Oliveira, S.H. Silva, B.M. Assis, L.B. Acurcio, L.L. Santos, J. L. Alves, H.C. Assis, A. T. Vieira, A.M. Caetano Faria, E. Ferreira, Y. Le Loir, G. Jan, L. R. Goulart, V.A. Azevedo, R.D.D.O. Carvalho, F.L.R. Do Carmo. 2018. Whey protein isolate-supplemented beverage fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138 in the prevention of mucositis in mice. Front. Microbiol. 9:2035.
doi: 10.3389/fmicb.2018.02035.

F.L. R. Do Carmo, W. Marques Silva, G. Campos Tavares, I. Coimbra Ibraim, B. Fernandes Cordeiro, E. Rosa Oliveira, H. Rabah, C. Cauty, S.H. Silva, M. Canário, A.C. Barbosa Caetano, R. Gonçalves Santos, R. Dias De Oliveira Carvalho, J. Jardin, F.L. Pereira, E.L. Folador, Y. Le Loir, H.C. Pereira Figueiredo, G. Jan, V. A. Azevedo. 2018. Mutation of the surface layer protein SlpB has pleiotropic effects in the probiotic Propionibacterium freudenreichii 129. Front Microbiol. 9:1807.
doi: 10.3389/fmicb.2018.01807.

N.R. Tartaglia, K. Breyne, C. Cauty, J. Jardin, D. Chrétien; K. Demeyere, N. Berkova, V. Azevedo, E. Meyer, E. Guedon, Y. Le Loir. 2018. Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in experimental mouse of mastitis. Front Cell Infect Microbiol. 8:277.
doi: 10.3389/fcimb.2018.00277.ol.

R. F. S. Souza, L. Rault, N. Seyffert, V. Azevedo, Y. Le Loir and S. Even. 2018. Lactobacillus casei BL23 modulates the innate immune response in Staphylococcus aureus-stimulated bovine mammary epithelial cells. Beneficial Microbes. 25:1-12.
doi: 10.3920/BM2018.0010.

Fillipe Luiz R. Carmo, Houem Rabah, Rodrigo De Oliveira Carvalho, Floriane Gaucher, Bárbara F.Cordeiro, Sara H. da Silva, Yves Le Loir, Vasco A. Azevedo, and Gwénaël Jan. 2018. Bacterial extractable surface proteins in probiotic / host interaction. Front. Microbiol. 9:645.
doi: 10.3389/fmicb.2018.00645.

Declaration of invention and of valorizable results (patenting process ongoing)

Patent: NEW TREATMENT AGAINST MUCOSITIS. international patent application, filed on 04/09/2019, under priority of the French application FR1870991, was registered by the EPO under the number: PCT / EP2019 / 073626. Inventors: Dr Gwénaël Jan, Dr Yves Le Loir, Dr Fillipe Luiz Rosa do Carmo, Pr Vasco Azevedo, Dr Rodrigo Dias de Oliveira Carvalho, Dr Barbara Fernandes Cordeiro, Dr Florence Valence.

Do Carmo F., Azevedo V., Le Loir Y., De Oliveira Carvalho R.D., Cordeiro B.F., Valence F., Jan G. 2018. Milk fermented by the probiotic Propionibacterium freudenreichii preventively attenuates chemotherapy-induced mucositis in a murine model.